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KMID : 1134820190480030306
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 3 p.306 ~ p.312
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Effects of Chondroitin on Blood Related Pathologic Factor and Weight Bearing in MIA Osteoarthritis Model
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Min Ga-Yul
Park Jong-Min
Joo In-Hwan
Sim Boo-Yong
Choi Hak-Joo
Kim Hwa-Young
Kim Jin
Lee Myung-Sun
Kim Dong-Hee
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Abstract
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Osteoarthritis is a disease that affects the articular cartilage and osseous tissue, and can be worsened by aging, overweight status, and post-traumatic arthritis. The present study examined the effects of chondroitin on the bone metabolism and the inflammatory response in a monosodium iodoacetate (MIA)-induced rat model of osteoarthritis. Chondroitin was administered orally at doses of 300 mg/kg, 600 mg/kg, or 900 mg/kg for 2 weeks before a direct injection of monosodium iodoacetate (3 mg/50 μL of 0.9% saline) into the intra-articular space of the rats’ right knees. The rats subsequently received the same doses of oral chondroitin for another 4 weeks. The treatment effects were evaluated based on serum bio-markers and weight-bearing distribution, and morphological analysis of the knee joints. Compared to the control rats, the chondroitin treatments reduced significantly the serum concentrations of inflammation and bone destruction markers (i.e., COX-2, PGE2, LTB4, CTX-Ⅱ, and COMP), and increased significantly the concentrations of bone regeneration markers, ACAN and GAGs. In addition, the chondroitin treatments effectively preserved the knee cartilage and the destruction in tip of a femur. Moreover, the chondroitin treatments increased the weight-bearing distribution by 7∼24%. The results suggest that chondroitin prevented and alleviated the osteoarthritis symptoms. Hence, chondroitin may be a novel heath food material for the management of osteoarthritis. Therefore, high concentrations of chondroitin may be a novel health food material to manage clinical osteoarthritis in human patient
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KEYWORD
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osteoarthritis, chondroitin, monosodium iodoacetate (MIA), health food
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